McGuire has been hit with a grade three dangerous contact charge, an offence that carries a base penalty of 300 points, or three matches.
However, McGuire's carry over points and poor record – he has a host of prior offences – means he's looking at five weeks out if he pleads guilty, and seven weeks on the sideline if he's found guilty at the judiciary.
In further bad news for the Dragons, fellow back-rower Tyrell Fuimaono is also facing an extended ban.
Fuimaono is facing a grade one reckless high tackle charge for the ugly hit that saw Melbourne's Ryan Papenhuyzen stretchered off. With loadings, Fuimaono will miss five weeks with an early plea, and six weeks if he takes his chances at the judiciary.
Nine's Phil Gould was left shaking his head at Fuimaono's actions, given the NRL had made it clear before the weekend started they would come down hard on any offences.
"It is incomprehensible to think a player would come up with a hit like that at this stage of the weekend after everything we've seen. On any weekend that was a send-off," he said during commentary.
In a horror day for the Dragons, they also have Mikaele Ravalawa and Tariq Sims looking at potential bans.
Ravalawa is looking at two to three weeks on the sideline for a shoulder charge on Justin Olam, while Sims will miss one to two weeks for a grade two dangerous contact charge.
Gold Coast could be without both Tyrone Peachey and Herman Ese'ese, after they were charged following the Titans' loss to Penrith.
Peachey will miss two weeks for a crusher tackle, regardless of whether he takes the early plea or not, while Ese'ese is looking at three or four weeks out for his high shot on Brian To'o.
MORE TO COME.
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